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Symbol Name ID |
Smo
smoothened, frizzled class receptor MGI:108075 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Colon cancer |
Intestinal pseudo-obstruction |
Intermittent diarrhea |
Nausea and vomiting |
Functional intestinal obstruction |
Neoplasm of the liver |
Hepatocellular carcinoma |
| Disease(s) Associated with SMO | |||||||
| hepatocellular carcinoma | |||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal intestinal goblet cell morphology |
abnormal enterocyte proliferation |
absent tongue |
digestive/alimentary phenotype |
abnormal intestine development |
abnormal intestinal enteroendocrine cell morphology |
abnormal intestinal smooth muscle morphology |
intestine polyps |
gastric polyps |
abnormal intestine physiology |
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| Availability | Mouse Genotype | ||||||||||
| Smotm1Amc/Smotm1Amc Tg(Pdx1-cre)6Tuv/0 (conditional) |
* | ||||||||||
| Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ Nkx3-2tm1(cre)Wez/Nkx3-2+ (conditional) |
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| Smotm1Amc/Smotm2Amc H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/? Tg(CAG-cre/Esr1*)5Amc/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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